IL23R (Human) Recombinant Protein
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More Files
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Specification
Product Description
Human IL23R (Q5VWK5-1, Gly24-Gly355) partial recombinant protein with His tag at C-terminus expressed in HEK293 cells.
Sequence
Gly24-Gly355
Host
Human
Theoretical MW (kDa)
39.15
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human IL-23R is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human IL-23R on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SPR
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human IL-23R, His Tag at 5 ug/mL (100 uL/mL/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha & IL-12 beta, His Tag with the EC50 of 0.87 ug/mL determined by ELISAFunctional Study
SDS-PAGE
Surface Plasmon Resonance
Human IL-23R, His Tag immobilized on CM5 Chip can bind Human IL-23 alpha & IL-12 beta, His Tag with an affinity constant of 5.72 nM as determined in SPR assay (Biacore T200). -
Gene Info — IL23R
Entrez GeneID
149233Protein Accession#
Q5VWK5-1Gene Name
IL23R
Gene Alias
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Gene Description
interleukin 23 receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq
Other Designations
OTTHUMP00000010660
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Pathway
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Disease
- Acute Disease
- Anemia
- Arthritis
- Asthma
- Atherosclerosis
- Autoimmune Diseases
- Behcet Syndrome
- Bipolar Disorder
- Bronchiolitis
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