CDK2AP1 (Human) Recombinant Protein
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Specification
Product Description
Human CDK2AP1 (O14519, 1 a.a. - 115 a.a.) full recombinant protein with His tag at N-terminus expressed in Escherichia coli.
Sequence
RGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSHMSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS
Host
Escherichia coli
Theoretical MW (kDa)
16.6
Form
Liquid
Preparation Method
Escherichia coli expression system
Purity
> 95.0% by SDS-PAGE
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In 20mM Tris-HCl pH 8.0 (0.1 M NaCl and 10% glycerol)
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — CDK2AP1
Entrez GeneID
8099Protein Accession#
O14519Gene Name
CDK2AP1
Gene Alias
DOC1, DORC1, ST19, doc-1, p12DOC-1
Gene Description
cyclin-dependent kinase 2 associated protein 1
Omim ID
602198Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. [provided by RefSeq
Other Designations
CDK2-associated protein 1|CDK2-associated protein 1|Deleted in oral cancer-1|cyclin-dependent kinase 2-associated protein 1|putative oral cancer suppressor
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Interactome
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