CDA (Human) Recombinant Protein
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Specification
Product Description
Human CDA (P32320, 1 a.a. - 146 a.a.) full recombinant protein with His tag at N-terminus expressed in Escherichia coli.
Sequence
MGSSHHHHHHSSGLVPRGSHMAQKRPACTLKPECVQQLLVCSQEAKQSAYCPYSHFPVGAALLTQEGRIFKGCNIENACYPLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKPDGTYIVMTVQELLPSSFGPEDLQKTQ
Host
Escherichia coli
Theoretical MW (kDa)
18.3
Form
Liquid
Preparation Method
Escherichia coli expression system
Purity
> 90.0% by SDS-PAGE
Activity
Specific activity is >> 10000 pmol/min/ug, and is defined as the amount of required to deaminate 1.0 pmole of cytidine per min at pH 7.5 at 25°C
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In 20mM Tris-HCl pH 8.0 (100 mM NaCl, 1 mM DTT, 2 mM EDTA and 40% glycerol)
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — CDA
Entrez GeneID
978Protein Accession#
P32320Gene Name
CDA
Gene Alias
CDD
Gene Description
cytidine deaminase
Omim ID
123920Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq
Other Designations
OTTHUMP00000002883|cytidine aminohydrolase|cytosine nucleoside deaminase|small cytidine deaminase
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Interactome
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