NPHS2 (Human) Recombinant Protein
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Specification
Product Description
Human NPHS2 (Q9NP85, 125 a.a. - 383 a.a.) partial recombinant protein with His tag at N-terminus expressed in Escherichia coli.
Sequence
MKHHHHHHASVKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHEIVTKDMFIMEIDAICYYRMENASLLLSSLAHVSKAVQFLVQTTMKRLLAHRSLTEILLERKSIAQDAKVALDSVTCIWGIKVERIEIKDVRLPAGLQHSLAVEAEAQRQAKVRMIAAEAEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTEKPSTVVLPLPFDLLNCLSSPSNRTQGSLPFPSPSKPVEPLNPKKKDSPML
Host
Escherichia coli
Theoretical MW (kDa)
30.2
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 95.0% by SDS-PAGE
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.1 M Acetate buffer pH 4.0
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — NPHS2
Entrez GeneID
7827Protein Accession#
Q9NP85Gene Name
NPHS2
Gene Alias
PDCN, SRN1
Gene Description
nephrosis 2, idiopathic, steroid-resistant (podocin)
Gene Ontology
HyperlinkGene Summary
This gene encodes the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. Defects in this gene are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN). SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000033186|podocin
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Interactome
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Disease
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