TNFRSF1B (Human) Recombinant Protein
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Specification
Product Description
Human TNFRSF1B recombinant proteind expressed in CHO Cells.
Host
Mammals
Theoretical MW (kDa)
75
Form
Lyophilized
Preparation Method
Mammalian cell (CHO) expression system
Purification
chromatographic
Purity
> 98% as determined by (a) RP-HPLC.(b) SDS-PAGE.
Activity
Potency is determined by the ability to neutralize TNF-alpha mediated growth inhibition of A375 cells, corresponding to a Specific Activity of 1.7 x 107 IU/mg.
Storage Buffer
Each mg contains 1.6 mg mannitol, 0.4 mg sucrose and 48 ug tromethamine. Reconstitute the lyophilized powder in ddH2O to 100 ug/mL.
Storage Instruction
Lyophilized protein at room temperature for 3 weeks, should be stored at -20°C. Protein aliquots at 4°C for 2-7 days and should be stored at -20°C to -80°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — TNFRSF1B
Entrez GeneID
7133Protein Accession#
P20333Gene Name
TNFRSF1B
Gene Alias
CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
Gene Description
tumor necrosis factor receptor superfamily, member 1B
Omim ID
191191Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq
Other Designations
OTTHUMP00000001784|p75 TNF receptor|soluble TNFR1B variant 1|tumor necrosis factor beta receptor|tumor necrosis factor binding protein 2|tumor necrosis factor receptor 2
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