LTA (Human) Recombinant Protein
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Specification
Product Description
Human LTA partial recombinant protein with His tag in N-terminus expressed in Escherichia coli.
Sequence
MGSSHHHHHHSSGLVPRGSHMLPGVGLTPSAAQTARQHPKMHLAHSTLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSGKAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAAFQLTQGDQLSTHTDGIPHLVLSPSTVFFGAFAL.
Host
Escherichia coli
Theoretical MW (kDa)
20.9
Form
Liquid
Preparation Method
Escherichia coli expression system
Purification
chromatographic
Purity
> 90% as determined by SDS-PAGE.
Activity
ED50 ≤ 0.3 ng/mL, measured by the cytolysis of murine L929 cells in the presence of Actinomycin D.
Storage Buffer
Solution (0.25 mg/mL) containing 20 mM Tris-HCl, pH 8.0, 30% glycerol, 0.1 M NaCl, 1 mM DTT.
Storage Instruction
Store at 4°C for one weeks and should be stored at -20°C to -80°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — LTA
Entrez GeneID
4049Protein Accession#
P01374Gene Name
LTA
Gene Alias
LT, TNFB, TNFSF1
Gene Description
lymphotoxin alpha (TNF superfamily, member 1)
Omim ID
153440Gene Ontology
HyperlinkGene Summary
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis
Other Designations
OTTHUMP00000029184|OTTHUMP00000037612|OTTHUMP00000037613|OTTHUMP00000165897|lymphotoxin alpha|tumor necrosis factor beta
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