GRN (Human) Recombinant Protein
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Specification
Product Description
Human GRN (P28799, 1 a.a. - 593 a.a.) partial-length recombinant protein expressed in HEK293 cell.
Host
Human
Theoretical MW (kDa)
74
Form
Lyophilized
Preparation Method
HEK 293T cell expression system
Purity
> 98% by SDS PAGE
Activity
Activates phospho-ERK1/2 in neuronal mouse P19 cells and regulates food intake and body weight.
Storage Buffer
1xPBS.
Storage Instruction
Store at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
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Applications
Functional Study
SDS-PAGE
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Gene Info — GRN
Entrez GeneID
2896Protein Accession#
P28799Gene Name
GRN
Gene Alias
GEP, GP88, PCDGF, PEPI, PGRN
Gene Description
granulin
Gene Ontology
HyperlinkGene Summary
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq
Other Designations
PC cell-derived growth factor|acrogranin|granulin-epithelin|proepithelin|progranulin
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