NRGN (Human) Recombinant Protein
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Specification
Product Description
Human NRGN (Q92686, 1 a.a. - 78 a.a.) partial-length recombinant protein expressed in Escherichia coli.
Sequence
MGSSHHHHHHSSGLVPRGSHMGSMDCCTENACSKPDDDILDIPLDDPGANAAAAKIQASFRGHMARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD.
Host
Escherichia coli
Theoretical MW (kDa)
10
Form
Liquid
Preparation Method
Escherichia coli expression system
Purity
> 90% by SDS PAGE
Storage Buffer
20mM Tris-HCl buffer (pH7.0), 30% glycerol 0.1mM PMSF and 1mM EDTA.
Storage Instruction
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles. -
Applications
SDS-PAGE
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Gene Info — NRGN
Entrez GeneID
4900Protein Accession#
Q92686Gene Name
NRGN
Gene Alias
RC3, hng
Gene Description
neurogranin (protein kinase C substrate, RC3)
Omim ID
602350Gene Ontology
HyperlinkGene Summary
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq
Other Designations
calmodulin-binding protein|neurogranin|protein kinase C substrate
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