KCNA1 (Human) Recombinant Protein
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Specification
Product Description
Human KCNA1 (P21741) recombinant protein with His tag at N-Terminus expressed in Escherichia coli.
Sequence
MKHHHHHHHMKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGTCGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETIRVTKPCTPKTKAKAKAKKGKGKD.
Host
Escherichia coli
Theoretical MW (kDa)
14.6
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 95% by SDS PAGE
Storage Buffer
Lyophilized from 0.1M NaCl, pH 7.2.
Storage Instruction
Store at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
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Applications
SDS-PAGE
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Gene Info — KCNA1
Entrez GeneID
3736Protein Accession#
P21741Gene Name
KCNA1
Gene Alias
AEMK, EA1, HBK1, HUK1, KV1.1, MBK1, MGC126782, MGC138385, MK1, RBK1
Gene Description
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
Gene Ontology
HyperlinkGene Summary
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq
Other Designations
potassium voltage-gated channel subfamily A member 1|voltage-gated potassium channel subunit Kv1.1
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Interactome
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Disease
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