LEP (Human) Recombinant Protein
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Specification
Product Description
Human LEP (P41159, L39A ,D40A, F41A) mutant recombinant protein with Ala at N-terminal expressed in Escherichia coli.
Host
Escherichia coli
Theoretical MW (kDa)
16
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 98% by Gel filtration analysis and SDS PAGE
Storage Buffer
Lyophilized from 0.0045mM NaHCO3.
Storage Instruction
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles. -
Applications
Functional Study
SDS-PAGE
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Gene Info — LEP
Entrez GeneID
3952Protein Accession#
P41159Gene Name
LEP
Gene Alias
FLJ94114, OB, OBS
Gene Description
leptin
Omim ID
164160Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq
Other Designations
leptin (murine obesity homolog)|leptin (obesity homolog, mouse)|obese, mouse, homolog of|obesity factor
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