IL31 (Human) Recombinant protein
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Specification
Product Description
Human IL31 (Q6EBC2, 24 a.a. - 164 a.a) partial recombinant protein expressed in Escherichia Coli.
Sequence
SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T.
Host
Escherichia coli
Theoretical MW (kDa)
15.8
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 95% by SDS-PAGE.
> 95% by SEC-HPLC.Activity
The ED50 was determined by the ability to activate STAT following receptor ligand interaction and found to be < 5 ng/mL, corresponding to a specific activity of 200,000 units.
Storage Buffer
Lyophilized from 20mM Phosphate buffer, 150mM NaCl, pH 7.4
Storage Instruction
Lyophilized although stable at room temperature for 3 weeks. should be stored desiccated below -20°C. Upon reconstitution should be stored at 4°C between 2-7 days and for future use below -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — IL31
Entrez GeneID
386653Protein Accession#
Q6EBC2Gene Name
IL31
Gene Alias
IL-31
Gene Description
interleukin 31
Omim ID
609509Gene Ontology
HyperlinkGene Summary
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM
Other Designations
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Interactome
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