GFRA1 (Human) Recombinant Protein
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Specification
Product Description
Human GFRA1 partial recombinant protein with His tag in C-terminus expressed in HEK293 cells.
Sequence
DRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFISVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGLGASHHHHHHHHHH
Host
Human
Theoretical MW (kDa)
46
Form
Lyophilized
Preparation Method
Mammalian cell (HEK 293) expression system
Purity
> 95% as determined by SDS-PAGE.
Storage Buffer
Protein (0.5 mg/mL) was lyophilized from a solution containing 1X PBS, pH 7.5, 5% w/v trehalose. Reconstitute the lyophilized powder in ddH2O to 0.5mg/mL, and is not sterile! Please filter the product by an sterile filter before use.
Storage Instruction
Lyophilized protein should be stored at -20°C. Protein aliquots at 4°C for two weeks.
Avoid repeated freeze/thaw cycles. -
Applications
SDS-PAGE
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Gene Info — GFRA1
Entrez GeneID
2674Protein Accession#
P56159Gene Name
GFRA1
Gene Alias
GDNFR, GDNFRA, GFR-ALPHA-1, MGC23045, RET1L, RETL1, TRNR1
Gene Description
GDNF family receptor alpha 1
Omim ID
601496Gene Ontology
HyperlinkGene Summary
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq
Other Designations
GPI-linked anchor protein|Glial cell line-derived neurotrophic factor receptor alpha|OTTHUMP00000020558|OTTHUMP00000020559|PI-linked cell-surface accessory protein|RET ligand 1|TGF-beta related neurotrophic factor receptor 1
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Interactome
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Disease
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