FGF12 (Human) Recombinant Protein
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Specification
Product Description
Human FGF12 recombinant protein expressed in?Escherichia coli.
Sequence
MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREQSLHEIGEKQGRSRKSSGTPTMNGGKVVNQDST
Host
Escherichia coli
Theoretical MW (kDa)
20.5
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purification
chromatography
Purity
> 98% as determined by (a) RP-HPLC.(b) SDS-PAGE.
Activity
Determined by FGF12 binding ability in a functional ELISA. Immobilized FGFR4/Fc Chimera at 5 ug/mL (100 uL/well) can bind FGF12 with a linear range of 1.6100 ng/mL.
Storage Buffer
Lyophilized from a solution containing 1X PBS, pH7.4, 1mM DTT. Reconstitute the lyophilized powder in ddH2O to 100 ug/mL.
Storage Instruction
Lyophilized protein at room temperature for 3 weeks, should be stored at -20°C. Protein aliquots at 4°C for 2-7 days and should be stored at -20°C to -80°C.
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — FGF12
Entrez GeneID
2257Protein Accession#
P61328Gene Name
FGF12
Gene Alias
FGF12B, FHF1
Gene Description
fibroblast growth factor 12
Omim ID
601513Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
fibroblast growth factor 12B|fibroblast growth factor FGF-12b|fibroblast growth factor homologous factor 1|myocyte-activating factor
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