NPPB (Human) Recombinant Protein
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Specification
Product Description
Human NPPB (P16860) recombinant protein expressed in Escherichia coli.
Sequence
SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH.
Host
Escherichia coli
Theoretical MW (kDa)
3.5
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 97% by HPLC and SDS PAGE
Storage Buffer
Natriuretic Peptide Precursor B was lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.4.
Storage Instruction
Store at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles.
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Applications
SDS-PAGE
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Gene Info — NPPB
Entrez GeneID
4879Protein Accession#
P16860Gene Name
NPPB
Gene Alias
BNP
Gene Description
natriuretic peptide precursor B
Omim ID
600295Gene Ontology
HyperlinkGene Summary
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq
Other Designations
OTTHUMP00000002506|OTTHUMP00000044486|brain type natriuretic peptide|natriuretic protein
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