ARTN (Human) Recombinant Protein,homodimer
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Specification
Product Description
Human ARTN (Q5T4W7) recombinant protein expressed in Escherichia coli.
Sequence
AGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCLG.
Host
Escherichia coli
Theoretical MW (kDa)
24.2
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Purity
> 98% by HPLC and SDS PAGE
Activity
The activity is determined by the dose-dependent proliferation of the SH-SY5Y cell line and is typically 4-8 ng/mL. The activity can also be determined by the ability to promote survival and neurite outgrowth.
Storage Buffer
Lyophilized from 10mM sodium citrate pH 4.5 and 25mM sodium chloride.
Storage Instruction
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles. -
Applications
Functional Study
SDS-PAGE
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Gene Info — ARTN
Entrez GeneID
9048Protein Accession#
Q5T4W7Gene Name
ARTN
Gene Alias
ENOVIN, EVN, NBN
Gene Description
artemin
Omim ID
603886Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000009173|OTTHUMP00000009174|neublastin|neurotrophic factor|neurotrophic factor artemin
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