IFNAR2 (Human) Recombinant Protein
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Specification
Product Description
Human IFNAR2 (P48551, 27 a.a. - 243 a.a.) partial length recombinant protein hIgG-His tag expressed in Baculovirus expression system.
Sequence
LMVYISLVFGISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAK
Host
Viruses
Theoretical MW (kDa)
51.7
Form
Liquid
Preparation Method
Baculovirus expression system
Purity
> 90% by SDS-PAGE
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
ED50 is < 500 ng/mL, measured by the binding ability in a functional ELISA with Human IFN-alpha 2.
Quality Control Testing
3 ug by SDS-PAGE under reducing condition and visualized by Coomassie blue stain.
Storage Buffer
In Phosphate-Buffer Saline pH 7.4 (10% glycerol)
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — IFNAR2
Entrez GeneID
3455Protein Accession#
P48551Gene Name
IFNAR2
Gene Alias
IFN-R, IFN-alpha-REC, IFNABR, IFNARB
Gene Description
interferon (alpha, beta and omega) receptor 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000067674|OTTHUMP00000067676|human interferon alpha/beta receptor|interferon alpha/beta receptor 2|interferon-alpha/beta receptor beta chain|type I interferon receptor
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