PRCP (Human) Recombinant Protein
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More Files
- More Functions
SDS-PAGE analysis of PRCP (Human) Recombinant Protein.
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Specification
Product Description
Human PRCP (P42785, 22 a.a. - 496 a.a.) partial recombinant protein with His tag expressed in HEK293 cells.
Sequence
LRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQ
Host
Human
Theoretical MW (kDa)
54.3
Form
Liquid
Preparation Method
Mammalian cell (HEK 293) expression system
Purity
> 95% as analyzed by SDS-PAGE.
Endotoxin Level
< 1 EU/ug of protein by the LAL method.
Activity
The specific activity is > 3000 pmol/min/ug, and is defined as the amount of enzyme that convert 1.0 pmole of Z-Pro-Ala-OH per minute at pH 4.0 at 25°C.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue.
SDS-PAGE analysis of PRCP (Human) Recombinant Protein.
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (30% glycerol)
Storage Instruction
Store at 4°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — PRCP
Entrez GeneID
5547Protein Accession#
P42785Gene Name
PRCP
Gene Alias
HUMPCP, MGC2202, PCP
Gene Description
prolylcarboxypeptidase (angiotensinase C)
Omim ID
176785Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
angiotensinase C|lysosomal Pro-x carboxypeptidase|lysosomal carboxypeptidase C|proline carboxypeptidase|prolylcarboxypeptidase|prolylcarboxypeptidase isoform 1 preproprotein
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Interactome
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Disease
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