TNFSF4 (Human) Recombinant Protein
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Specification
Product Description
Human TNFSF4 (P23510, 51 a.a. - 183 a.a.) partial recombinant protein with His-Flag tag at N-terminus expressed in Expi293 cells.
Sequence
QVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL
Host
Mammals
Theoretical MW (kDa)
65-140
Form
Lyophilized
Preparation Method
Mammalian cell (Expi293) expression system
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
Immobilized Human OX40L (Trimer), His & Flag Tag at 1.0 ug/mL (100 uL/Well). Dose response curve for Human OX40, hFc Tag with the EC50 of 0.09 ug/mL determined by ELISA.
Quality Control Testing
SDS-PAGE under reducing condition
Storage Buffer
Lyophilized from sterile distilled Water up to 100 ug/mL
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — TNFSF4
Entrez GeneID
7292Protein Accession#
P23510Gene Name
TNFSF4
Gene Alias
CD134L, CD252, GP34, OX-40L, OX4OL, TXGP1
Gene Description
tumor necrosis factor (ligand) superfamily, member 4
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq
Other Designations
CD134 ligand|OTTHUMP00000032704|OX40 antigen ligand|OX40 ligand|glycoprotein 34 kd|tax-transcriptionally activated glycoprotein 1 (34kD)
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Pathway
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Disease
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