PVR (Human) Recombinant Protein
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More Files
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Result of bioactivity analysis
Result of bioactivity analysis
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Specification
Product Description
Human PVR (P15151, 21 a.a. - 343 a.a.) partial recombinant protein with hFc tag at C-terminus expressed in HEK293 cells.
Sequence
WPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGISRN
Host
Mammals
Theoretical MW (kDa)
85-105
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 97% by SDS-PAGE
Endotoxin Level
< 0.2 EU per 1 ug of protein (determined by gel clotting method)
Activity
Immobilized PVR/CD155, hFc, Human at 5.0 ug/mL (100 uL/well) can bind biotinylated TIGIT, hFc, Human when detected by Streptavidin-HRP.
Storage Buffer
Lyophilized from sterile distilled Water up to 100 ug/mL
Storage Instruction
Store at 4°C to 8°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — PVR
Entrez GeneID
5817Protein Accession#
P15151Gene Name
PVR
Gene Alias
CD155, FLJ25946, HVED, NECL5, Necl-5, PVS, TAGE4
Gene Description
poliovirus receptor
Omim ID
173850Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
nectin-like 5
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Interactome
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Pathway
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Disease
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