VEGFC (Human) Recombinant Protein
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Specification
Product Description
Human VEGFC (P49767, 112 a.a. - 227 a.a.) partial recombinant protein expressed with an N-terminal Met in HEK293 cells.
Sequence
AHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRR
Host
Human
Theoretical MW (kDa)
16 ~ 19
Form
Lyophilized
Preparation Method
Mammalian cell (HEK 293) expression system
Purity
> 95% as analyzed by SDS-PAGE.
Endotoxin Level
< 0.2 EU/ ug of protein (gel clotting method)
Activity
ED50 < 0.5 ug/mL, measured in a cell proliferation assay using HMVEC human microvascular endothelial cells.
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS. Reconstitute the lyophilized powder in ddH2O or PBS up to 100 ug/mL.
Storage Instruction
Store at 4°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — VEGFC
Entrez GeneID
7424Protein Accession#
P49767Gene Name
VEGFC
Gene Alias
Flt4-L, VRP
Gene Description
vascular endothelial growth factor C
Omim ID
601528Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq
Other Designations
FLT4 ligand DHM|vascular endothelial growth factor-related protein
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