PPBP (Human) Recombinant Protein
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Specification
Product Description
Human PPBP (P02775, 59 a.a. - 128 a.a.) partial recombinant protein expressed in CHO cells.
Sequence
AELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD
Host
Mammals
Theoretical MW (kDa)
~ 9
Form
Lyophilized
Preparation Method
_x005F_x000D__x000D_ Mammalian cell (CHO) expression system_x005F_x000D__x000D_
Purity
> 98% as analyzed by SDS-PAGE.
Endotoxin Level
< 0.2 EU/ ug of protein (gel clotting method)
Activity
Human PPBP EC50 < 0.1 ug/mL, measured on Ca2+ mobilization assay in CHO-K1/ Galpha15/hCXCR1 cells (human Galpha15 and human CXCR1 stably expressed in CHO-K1 cells).
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS. Reconstitute the lyophilized powder in ddH2O up to 100 ug/mL.
Storage Instruction
Store at 4°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — PPBP
Entrez GeneID
5473Protein Accession#
P02775Gene Name
PPBP
Gene Alias
B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1
Gene Description
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
Omim ID
121010Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and sythesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. [provided by RefSeq
Other Designations
CXC chemokine ligand 7|beta-thromboglobulin|connective tissue-activating peptide III|leukocyte-derived growth factor|low-affinity platelet factor IV|macrophage-derived growth factor|neutrophil-activating peptide 2|neutrophil-activating peptide-2|platelet
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Interactome
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Disease
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