CCL5 (Human) Recombinant Protein
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Specification
Product Description
Human CCL5 (P13501, 24 a.a. - 91 a.a.) partial recombinant protein expressed in HEK293 cells.
Sequence
SPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS
Host
Human
Theoretical MW (kDa)
~ 8
Form
Lyophilized
Preparation Method
_x005F_x000D__x000D_ Mammalian cell (HEK 293) expression system_x005F_x000D__x000D_
Purity
> 98% as analyzed by SDS-PAGE.
Endotoxin Level
< 0.2 EU/ ug of protein (gel clotting method)
Activity
Human CCL5 EC50 < 0.2 ug/mL, measured on Ca2+ mobilization assay in CHO-K1/ Galpha15/hCCR1 cells (human Galpha15 and human CCR1 stably expressed in CHO-K1 cells).
Recommend Usage
Biological Activity
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS. Reconstitute the lyophilized powder in ddH2O up to 100 ug/mL.
Storage Instruction
Store at 4°C for 1 week. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — CCL5
Entrez GeneID
6352Protein Accession#
P13501Gene Name
CCL5
Gene Alias
D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228
Gene Description
chemokine (C-C motif) ligand 5
Omim ID
187011Gene Ontology
HyperlinkGene Summary
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq
Other Designations
SIS-delta|T-cell specific RANTES protein|T-cell specific protein p288|beta-chemokine RANTES|regulated upon activation, normally T-expressed, and presumably secreted|small inducible cytokine A5|small inducible cytokine A5 (RANTES)|small inducible cytokine
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Interactome
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Disease
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