CNTF (Human) Recombinant Protein
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Specification
Product Description
Human CNTF (NP_000605, 1 - 200 a.a.) full length recombinant protein expressed in Escherichia coli expression system.
Host
Escherichia coli
Theoretical MW (kDa)
22.9
Form
Liquid
Preparation Method
Escherichia coli expression system
Purity
> 90% by SDS-PAGE
Endotoxin Level
< 1 EU/ug
Activity
Human CNTF stimulates cell proliferation of the TF-1 human erythroleukemic cells. The ED50 range ≤ 500 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
3 ug SDS-PAGE under reducing condition and visualized by coomassie blue stain.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
In 20 mM Tris-HCl, 1 mM DTT, pH 8.0 (10% glycerol)
Storage Instruction
Store at 4°C for one week. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
SDS-PAGE
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Gene Info — CNTF
Entrez GeneID
1270Protein Accession#
P26441Gene Name
CNTF
Gene Alias
HCNTF
Gene Description
ciliary neurotrophic factor
Omim ID
118945Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq
Other Designations
OTTHUMP00000174731
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