TNFSF8 (Human) Recombinant Protein
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Specification
Product Description
Human TNFSF8 (P32971) recombinant protein expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
65
Form
Lyophilized
Purity
> 97%
Endotoxin Level
<= 1 EUs/ug (LAL gel clot method)
Activity
The activity was tested by the ability of immobilized recombinant human CD30L to bind Human CD30 with a linear range of 300-2000 pg/mL.
Storage Buffer
Lyophilized from 0.2 um filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction
Stored at -20°C to-80°C.
After reconstitution with sterile water not less than 0.1 mg/mL, store at -20°C to -80°C for 12 months, store at 4°C for 1 month.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Functional Study
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Gene Info — TNFSF8
Entrez GeneID
944Protein Accession#
P32971Gene Name
TNFSF8
Gene Alias
CD153, CD30L, CD30LG, MGC138144
Gene Description
tumor necrosis factor (ligand) superfamily, member 8
Omim ID
603875Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. [provided by RefSeq
Other Designations
CD153 antigen|CD30 antigen ligand|CD30 ligand|OTTHUMP00000022762
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