GP1BA N37O/N175O (Human) Recombinant Protein
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Specification
Product Description
Human GP1BA (NP_000164, 17 a.a - 306 a.a) partial protein (unsulfated form) with C-terminal hexahistidine tag expressed in HEK293EBNA1 cells.
Host
Human
Theoretical MW (kDa)
33.5
Reactivity
Human
Form
Liquid
Preparation Method
Mammalian cell (HEK293EBNA1) expression system
Quality Control Testing
NuPAGE Stained with Coomassie Blue
Storage Buffer
In PBS without preservative
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — GP1BA
Entrez GeneID
2811GeneBank Accession#
NM_000173Protein Accession#
NP_000164Gene Name
GP1BA
Gene Alias
BSS, CD42B, CD42b-alpha, GP1B, MGC34595
Gene Description
glycoprotein Ib (platelet), alpha polypeptide
Gene Ontology
HyperlinkGene Summary
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq
Other Designations
platelet glycoprotein Ib alpha polypeptide|platelet membrane glycoprotein 1b-alpha subunit
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