DYRK3 (Human) Recombinant Protein
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Specification
Product Description
Human DYRK3 (NP_003573.2, 1 a.a. - 588 a.a.) full-length recombinant protein with GST tag expressed in baculovirus infected Sf21 cells.
Host
insect
Theoretical MW (kDa)
93
Form
Liquid
Preparation Method
Baculovirus infected insect cell (Sf21) expression system
Purification
Glutathione sepharose chromatography
Purity
93 % by SDS-PAGE/CBB staining
Activity
The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: DYRKtide-F. ATP: 100 uM.
Quality Control Testing
Loading 1 ug protein in SDS-PAGE
Storage Buffer
In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — DYRK3
Entrez GeneID
8444Protein Accession#
NP_003573.2Gene Name
DYRK3
Gene Alias
DYRK5, RED, REDK, hYAK3-2
Gene Description
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Omim ID
603497Gene Ontology
HyperlinkGene Summary
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
OTTHUMP00000034527|OTTHUMP00000034528|OTTHUMP00000034529|dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5|protein kinase Dyrk3|regulatory erythroid kinase
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