TYK2 monoclonal antibody, clone 8G8E9,8G9H5
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot
Western blot analyssi using TYK2 monoclonal antibody, clone 8G8E9, 8G9H5 (Cat # MAB8321) against trucated TYK2 recombinant protein (Lane 1) and Jurkat cell lysate (Lane 2).
-
Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant TYK2.
Immunogen
Recombinant protein corresponding to truncated human TYK2.
Host
Mouse
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:500-1:2000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Western blot analyssi using TYK2 monoclonal antibody, clone 8G8E9, 8G9H5 (Cat # MAB8321) against trucated TYK2 recombinant protein (Lane 1) and Jurkat cell lysate (Lane 2).Enzyme-linked Immunoabsorbent Assay
-
Gene Info — TYK2
Entrez GeneID
7297Gene Name
TYK2
Gene Alias
JTK1
Gene Description
tyrosine kinase 2
Omim ID
176941Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq
Other Designations
-
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.
Shaw MH, Freeman GJ, Scott MF, Fox BA, Bzik DJ, Belkaid Y, Yap GS.
Journal of Immunology 2006 Jun; 176(12):7263.
-
Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice.
Seto Y, Nakajima H, Suto A, Shimoda K, Saito Y, Nakayama KI, Iwamoto I.
The Journal of Immunology 2003 Jan; 172(2):1077.
-
Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com