TSHR monoclonal antibody, clone 3A6
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant TSHR.
Immunogen
Recombinant protein corresponding to full length human TSHR.
Host
Mouse
Reactivity
Human
Form
Liquid
Recommend Usage
Flow Cytometry (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2% Block Ace)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Flow Cytometry
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Gene Info — TSHR
Entrez GeneID
7253Gene Name
TSHR
Gene Alias
CHNG1, LGR3, MGC75129, hTSHR-I
Gene Description
thyroid stimulating hormone receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
seven transmembrane helix receptor|thyroid stimulating hormone receptor, isoform 2|thyrotropin receptor|thyrotropin receptor-I, hTSHR-I
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Interactome
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Pathway
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Disease
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Publication Reference
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An improved Graves' disease model established by using in vivo electroporation exhibited long-term immunity to hyperthyroidism in BALB/c mice.
Kaneda T, Honda A, Hakozaki A, Fuse T, Muto A, Yoshida T.
Endocrinology 2007 May; 148(5):2335.
Application:Flow Cyt, Mouse , CHO-K1 cells.
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Human melanoma cells express functional receptors for thyroid-stimulating hormone.
Ellerhorst JA, Sendi-Naderi A, Johnson MK, Cooke CP, Dang SM, Diwan AH.
Endocrine-Related Cancer 2006 Dec; 13(4):1269.
Application:IF, IHC, WB, Human, Human melanoma, MeWo cells, TAD cells, Thyrocytes, WM793 cells.
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TNFalpha mediates the skeletal effects of thyroid-stimulating hormone.
Hase H, Ando T, Eldeiry L, Brebene A, Peng Y, Liu L, Amano H, Davies TF, Sun L, Zaidi M, Abe E.
PNAS 2006 Aug; 103(34):12849.
Application:Flow Cyt, Mouse, Mouse bone marrow macrophages.
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An improved Graves' disease model established by using in vivo electroporation exhibited long-term immunity to hyperthyroidism in BALB/c mice.
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