KCNQ4 monoclonal antibody, clone S43-6
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of rat tissue (a blend of rat skeletal muscle, heart, brain, kidney, liver, lung, pancreas, testes, spleen, and thymus) mixed lysate with KCNQ4 monoclonal antibody, clone S43-6 (Cat # MAB6656).
Immunofluorescence
Immunofluorescence staining in human hippocampus with KCNQ4 monoclonal antibody, clone S43-6 (Cat # MAB6656).
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant KCNQ4.
Immunogen
Recombinant fusion protein corresponding to amino acids 2-77 of human KCNQ4.
Host
Mouse
Reactivity
Human, Mouse, Rat
Specificity
Detects ~77KDa.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1-10 ug/mL)
Immunohistochemistry (0.1-1.0 ug/mL)
Immunocytochemistry (0.1-1.0 ug/mL)
Immunofluorescence (1.0-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (50% glycerol, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of rat tissue (a blend of rat skeletal muscle, heart, brain, kidney, liver, lung, pancreas, testes, spleen, and thymus) mixed lysate with KCNQ4 monoclonal antibody, clone S43-6 (Cat # MAB6656).Immunocytochemistry
Immunofluorescence
Immunofluorescence staining in human hippocampus with KCNQ4 monoclonal antibody, clone S43-6 (Cat # MAB6656).Immunoprecipitation
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Gene Info — KCNQ4
Entrez GeneID
9132Protein Accession#
P56696Gene Name
KCNQ4
Gene Alias
DFNA2, KV7.4
Gene Description
potassium voltage-gated channel, KQT-like subfamily, member 4
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000009219|potassium channel KQT-like 4|potassium voltage-gated channel KQT-like protein 4
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Interactome
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Disease
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Publication Reference
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Congenital long QT syndrome.
Crotti L, Celano G, Dagradi F, Schwartz PJ.
Orphanet Journal of Rare Diseases 2008 Jul; 3:18.
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Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT.
Cell 2004 Oct; 119(1):19.
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Congenital long QT syndrome.
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