CD28 monoclonal antibody, clone CD28.2 (APC)
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Specification
Product Description
Mouse monoclonal antibody raised against CD28.
Immunogen
Native purified CD28 from DC28.1.3.3 hybridoma cells.
Host
Mouse
Theoretical MW (kDa)
44
Reactivity
Human, Non-Human Primates
Specificity
This antibody reacts with CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of MW 44 KDa) which is a critical costimulatory receptor of T cells.
Form
Liquid
Conjugation
APC
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — CD28
Entrez GeneID
940Gene Name
CD28
Gene Alias
MGC138290, Tp44
Gene Description
CD28 molecule
Omim ID
186760Gene Ontology
HyperlinkGene Summary
CD28 costimulation is essential for CD4 (MIM 186940)-positive T-cell proliferation, survival, interleukin-2 (IL2; MIM 147680) production, and T-helper type-2 (Th2) development.[supplied by OMIM
Other Designations
CD28 antigen|CD28 antigen (Tp44)|T-cell-specific surface glycoprotein
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Interactome
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Pathway
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Disease
- Acute Disease
- Arthritis
- Asthma
- Behcet Syndrome
- Bronchiolitis
- Carcinoma
- Celiac Disease
- Cholangitis
- Colon cancer
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Publication Reference
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Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates.
Jeong SH, Qiao M, Nascimbeni M, Hu Z, Rehermann B, Murthy K, Liang TJ.
Journal of Virology 2004 Jul; 78(13):6995.
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Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling.
Scharschmidt E, Wegener E, Heissmeyer V, Rao A, Krappmann D.
Molecular and Cellular Biology 2004 May; 24(9):3860.
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Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.
Marti F, Krause A, Post NH, Lyddane C, Dupont B, Sadelain M, King PD.
Journal of Immunology 2001 Jan; 166(1):197.
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Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates.
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