CD58 monoclonal antibody, clone MEM-63 (FITC)
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More Files
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Flow Cytometry
Surface staining of human peripheral blood cells with CD58 monoclonal antibody, clone MEM-63 (FITC) (Cat # MAB5006).
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Specification
Product Description
Mouse monoclonal antibody raised against native CD58.
Immunogen
Native purified CD58 from NALM-6 human pre-B cell line.
Host
Mouse
Theoretical MW (kDa)
40-70
Reactivity
Human, Pig
Specificity
This antibody reacts with CD58 (LFA-3), a 40-70 KDa glycoprotein distributed over many tissues, leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts.
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Surface staining of human peripheral blood cells with CD58 monoclonal antibody, clone MEM-63 (FITC) (Cat # MAB5006). -
Gene Info — CD58
Entrez GeneID
965Gene Name
CD58
Gene Alias
LFA-3, LFA3
Gene Description
CD58 molecule
Omim ID
153420Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq
Other Designations
CD58 antigen, (lymphocyte function-associated antigen 3)|OTTHUMP00000024363
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Interactome
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Pathway
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Disease
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Publication Reference
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Investigation on correlation between expression of CD58 molecule and severity of hepatitis B.
Sheng L, Li J, Qi BT, Ji YQ, Meng ZJ, Xie M.
World Journal of Gastroenterology 2006 Jul; 12(26):4237.
Application：Flow Cyt, Human, PBMCs of patients with HBV infection.
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Distinct membrane localization and kinase association of the two isoforms of CD58.
Ariel O, Kukulansky T, Raz N, Hollander N.
Cellular Signalling 2004 Jun; 16(6):667.
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Expression of CD58 in normal, regenerating and leukemic bone marrow B cells: implications for the detection of minimal residual disease in acute lymphocytic leukemia.
Veltroni M, De Zen L, Sanzari MC, Maglia O, Dworzak MN, Ratei R, Biondi A, Basso G, Gaipa G.
Haematologica 2003 Nov; 88(11):1245.
Application：Flow Cyt, Human, Leukemic bone marrow.
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Investigation on correlation between expression of CD58 molecule and severity of hepatitis B.
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