B3GAT1 monoclonal antibody, clone VC1.1
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Specification
Product Description
Mouse monoclonal antibody raised against native B3GAT1.
Immunogen
Native purified B3GAT1 from cat unfixed cortical homogenate area 17.
Host
Mouse
Reactivity
Human
Specificity
Recognizes a (110KDa) carbohydrate molecule on myeloid cells. This surface antigen is associated with myelin-associated glycoprotein (MAG). The CD57 antigen is present on 15-20% of normal peripheral blood mononuclear cells. It is expressed on a subset of natural killer cells (60%) and on a subset of T-lymphocytes. This carbohydrate is also present on N-CAM in the nervous system.
Form
Liquid
Isotype
IgM
Recommend Usage
Flow Cytometry (1ug stain 1.0x106 cells)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS, pH 7.2 (1% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Flow Cytometry
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Gene Info — B3GAT1
Entrez GeneID
27087Gene Name
B3GAT1
Gene Alias
CD57, GLCATP, GlcAT-P, GlcUAT-P, HNK-1, HNK1, LEU7, NK-1
Gene Description
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
Omim ID
151290Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. [provided by RefSeq
Other Designations
CD57 antigen|LEU7 antigen|UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase|beta-1,3-glucuronyltransferase 1|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1|glucuronosyltransferase P
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Interactome
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Pathway
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Publication Reference
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A carbohydrate epitope defined by monoclonal antibody VC1.1 is found on N-CAM and other cell adhesion molecules.
Naegele JR, Barnstable CJ.
Brain Research 1991 Sep; 559(1):118.
Application：IF, IP, WB, Cat, Rat, Cat cortex, Rat cortex.
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Molecular markers of neuronal subpopulations in layers 4, 5, and 6 of cat primary visual cortex.
Arimatsu Y, Naegele JR, Barnstable CJ.
Journal of Neuroscience 1987 Apr; 7(4):1250.
Application：IF, WB-Ti, Cat, Cat cortex.
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A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).
Abo T, Balch CM.
Journal of Immunology 1981 Sep; 127(3):1024.
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A carbohydrate epitope defined by monoclonal antibody VC1.1 is found on N-CAM and other cell adhesion molecules.
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