CD4 monoclonal antibody, clone MEM-16
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Specification
Product Description
Mouse monoclonal antibody raised against native CD4.
Immunogen
Native human peripheral blood leukemia T-cells.
Host
Mouse
Theoretical MW (kDa)
55
Reactivity
Human
Specificity
This antibody recognizes an epitope EF loop of D1 domain of CD4 antigen, a 55KDa transmebrane glycoprotein expressed on a subset of T lymphocytes (helper T-cells) and also on monocytes, tissue macrophages and granulocytes.
Form
Liquid
Concentration
1 mg/mL
Isotype
IgM
Recommend Usage
Flow Cytometry (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunoprecipitation
Flow Cytometry
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Gene Info — CD4
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Interactome
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Pathway
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Disease
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Publication Reference
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Cell surface receptors, virus entry and tropism of primate lentiviruses.
Clapham PR, McKnight A.
The Journal of General Virology 2002 Aug; 83(Pt 8):1809.
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p56Lck anchors CD4 to distinct microdomains on microvilli.
Foti M, Phelouzat MA, Holm A, Rasmusson BJ, Carpentier JL.
PNAS 2002 Feb; 99(4):2008.
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CD4 segregates into specific detergent-resistant T-cell membrane microdomains.
Millan J, Cerny J, Horejsi V, Alonso MA.
Tissue Antigens 1999 Jan; 53(1):33.
Application:IP, WB-Ce, Human, HPB-ALL cells.
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Cell surface receptors, virus entry and tropism of primate lentiviruses.
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