TNFRSF1B monoclonal antibody, clone 2H11C2
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human TNFRSF1B.
Immunogen
Recombinant protein corresponding to amino acids 23-257 of human TNFRSF1B.
Host
Mouse
Theoretical MW (kDa)
48.3
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:10000)
Flow Cytometry (1:200-1:400)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: TNFRSF1B-hIgGFc transfected HEK293 cell lysates with TNFRSF1B monoclonal antibody, clone 2H11C2 (Cat # MAB21378).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with TNFRSF1B monoclonal antibody, clone 2H11C2 (Cat # MAB21378).Flow Cytometry
Flow cytometric analysis of HL-60 cells with TNFRSF1B monoclonal antibody, clone 2H11C2 (Cat # MAB21378) (Green). Red: Negative Control. -
Gene Info — TNFRSF1B
Entrez GeneID
7133Protein Accession#
P20333Gene Name
TNFRSF1B
Gene Alias
CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
Gene Description
tumor necrosis factor receptor superfamily, member 1B
Omim ID
191191Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq
Other Designations
OTTHUMP00000001784|p75 TNF receptor|soluble TNFR1B variant 1|tumor necrosis factor beta receptor|tumor necrosis factor binding protein 2|tumor necrosis factor receptor 2
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