LRP2 monoclonal antibody, clone EE-12
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of 293T cell lysate with LRP2 monoclonal antibody, clone EE-12 (Cat # MAB20454).
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Specification
Product Description
Rabbit monoclonal antibody raised against synthetic peptide of human LRP2.
Immunogen
A synthetic peptide corresponding to human LRP2.
Host
Rabbit
Theoretical MW (kDa)
521.958
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide).
Storage Instruction
Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of 293T cell lysate with LRP2 monoclonal antibody, clone EE-12 (Cat # MAB20454). -
Gene Info — LRP2
Entrez GeneID
4036Protein Accession#
P98164Gene Name
LRP2
Gene Alias
DBS, gp330
Gene Description
low density lipoprotein-related protein 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR)
Other Designations
Heymann nephritis antigen homolog|calcium sensor protein|megalin
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Interactome
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Pathway
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Disease
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