GRM1 monoclonal antibody, clone 5E12D8
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human GRM1.
Immunogen
Recombinant protein corresponding to amino acids 387-486 of human GRM1.
Host
Mouse
Theoretical MW (kDa)
132.4
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: GRM1-hIgGFc transfected HEK293 cell lysates with GRM1 monoclonal antibody, clone 5E12D8 (Cat # MAB17943).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with GRM1 monoclonal antibody, clone 5E12D8 (Cat # MAB17943). -
Gene Info — GRM1
Entrez GeneID
2911Protein Accession#
Q13255Gene Name
GRM1
Gene Alias
GPRC1A, GRM1A, MGLUR1, MGLUR1A, mGlu1
Gene Description
glutamate receptor, metabotropic 1
Omim ID
604473Gene Ontology
HyperlinkGene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq
Other Designations
OTTHUMP00000017365
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