PRKAG3 monoclonal antibody, clone 1C5D10
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human PRKAG3.
Immunogen
Recombinant protein corresponding to amino acids 9-151 of human PRKAG3.
Host
Mouse
Theoretical MW (kDa)
54.3
Reactivity
Human
Form
Liquid
Isotype
IgG1
Recommend Usage
ELISA (1:10000)
Western Blot (1:100-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of Lane 1: HEK293 and Lane 2: PRKAG3-hIgGFc transfected HEK293 cell lysates with PRKAG3 monoclonal antibody, clone 1C5D10 (Cat # MAB17903).Enzyme-linked Immunoabsorbent Assay
ELISA analysis with PRKAG3 monoclonal antibody, clone 1C5D10 (Cat # MAB17903). -
Gene Info — PRKAG3
Entrez GeneID
53632Protein Accession#
Q9UGI9Gene Name
PRKAG3
Gene Alias
AMPKG3
Gene Description
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
Omim ID
604976Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq
Other Designations
5'-AMP-activated protein kinase, gamma-3 subunit|AMP-activated protein kinase, non-catalytic gamma-3 subunit|AMPK gamma-3 chain|OTTHUMP00000164095
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