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Western Blot (Transfected lysate)

Western Blot

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunofluorescence

Enzyme-linked Immunoabsorbent Assay

Flow Cytometry

Entrez GeneID

Gene Name

HLA-B

Gene Alias

AS, HLA-B-7301, HLA-B73, HLAB, HLAC, SPDA1

Gene Description

major histocompatibility complex, class I, B

Omim ID

Gene Ontology

Gene Summary

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq

Other Designations

HLA class I histocompatibility antigen, B alpha chain|HLA class I histocompatibility antigen, B-7 alpha chain|HLA class I histocompatibility antigen, Cw-5 alpha chain|HLA-B alpha chain (HLA-B*7301)|MHC Class I HLA heavy chain|MHC HLA-B cell surface glycop