VASP monoclonal antibody, clone IE273
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Specification
Product Description
Mouse monoclonal antibody raised against human VASP.
Immunogen
Purified human VASP.
Host
Mouse
Reactivity
Bovine, Human, Pig, Rabbit, Sheep
Specificity
Recognizes both the Ser157 dephosphorylated and Ser157 phosphorylated form of VASP.
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
Immunocytochemistry (1:100-500)
Western Blot (1:2000-50000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (2 mg/mL BSA, 0.02% sodium azide).
Storage Instruction
For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
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Gene Info — VASP
Entrez GeneID
7408Protein Accession#
P50552Gene Name
VASP
Gene Alias
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Gene Description
vasodilator-stimulated phosphoprotein
Omim ID
601703Gene Ontology
HyperlinkGene Summary
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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