REST monoclonal antibody, clone CL0381
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with REST monoclonal antibody, clone CL0381 (Cat # MAB15624) shows strong nuclear immunoreactivity in the lymphoid cells.
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human REST.
Immunogen
Recombinant protein corresponding to human REST.
Epitope
This antibody binds to an epitope located within the peptide sequence ISSSGQNLNT as determined by overlapping synthetic peptides.
Sequence
SPPLPKENLREEASGDQKLLNTGEGNKEAPLQKVGAEEADESLPGLAANINESTHISSSGQNLNTPEGETLNGKHQTDSIVCEMKMDTDQNTRENLTGINSTVEEPVSPMLPPSAVEEREAVSKTALA
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human tonsil with REST monoclonal antibody, clone CL0381 (Cat # MAB15624) shows strong nuclear immunoreactivity in the lymphoid cells. -
Gene Info — REST
Entrez GeneID
5978Protein Accession#
Q13127Gene Name
REST
Gene Alias
NRSF, XBR
Gene Description
RE1-silencing transcription factor
Omim ID
600571Gene Ontology
HyperlinkGene Summary
This gene encodes a transcriptional repressor which represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells, and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described; however, their full length nature has not been determined. [provided by RefSeq
Other Designations
neuron restrictive silencer factor|repressor binding to the X2 box
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Interactome
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Disease
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