Complement 4d monoclonal antibody, clone SPM545
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney transplant.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant human complement 4d.
Immunogen
Recombinant protein corresponding to human complement 4d.
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
ELISA (For coating use at 1-2 ug/mL without BSA)
Immunofluorescence (1:50-100)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:200-400)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS (0.05% BSA, 0.05% azide).
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney transplant.Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — C4B
Entrez GeneID
721Gene Name
C4B
Gene Alias
C4A, C4A13, C4A91, C4B1, C4B12, C4B2, C4B3, C4B5, C4F, CH, CO4, CPAMD3, FLJ60561, MGC164979
Gene Description
complement component 4B (Chido blood group)
Omim ID
120820Gene Ontology
HyperlinkGene Summary
This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq
Other Designations
Chido form of C4|OTTHUMP00000029269|basic C4|complement C4B1a|complement component 4B|complement component 4B (Childo blood group)
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Interactome
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Pathway
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Disease
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Publication Reference
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Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection.
Racusen LC, Colvin RB, Solez K, Mihatsch MJ, Halloran PF, Campbell PM, Cecka MJ, Cosyns JP, Demetris AJ, Fishbein MC, Fogo A, Furness P, Gibson IW, Glotz D, Hayry P, Hunsickern L, Kashgarian M, Kerman R, Magil AJ, Montgomery R, Morozumi K, Nickeleit V, Randhawa P, Regele H, Seron D, Seshan S, Sund S, Trpkov K.
American Journal of Transplantation 2003 Jun; 3(6):708.
Application：IF, Human, Human kidney.
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Footprints of humoral rejection.
Sacks SH, Chowdhury P.
Current Opinion in Nephrology and Hypertension 2002 Nov; 11(6):627.
Application：IHC-Fr, IHC-P, Human, Human kidney, Human tissues.
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Complement activation in acute humoral renal allograft rejection: diagnostic significance of C4d deposits in peritubular capillaries.
Collins AB, Schneeberger EE, Pascual MA, Saidman SL, Williams WW, Tolkoff-Rubin N, Cosimi AB, Colvin RB.
Journal of the American Society of Nephrology 1999 Oct; 10(10):2208.
Application：IF, Human, Renal allograft biopsies.
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Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection.
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