BRCA1 monoclonal antibody, clone BRCA1/1472
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant human BRCA1.
Immunogen
Recombinant protein corresponding to amino acids 445-620 of human BRCA1.
Host
Mouse
Theoretical MW (kDa)
220
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
ELISA
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
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Gene Info — BRCA1
Entrez GeneID
672Protein Accession#
P38398Gene Name
BRCA1
Gene Alias
BRCAI, BRCC1, IRIS, PSCP, RNF53
Gene Description
breast cancer 1, early onset
Omim ID
113705Gene Ontology
HyperlinkGene Summary
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq
Other Designations
BRCA1/BRCA2-containing complex, subunit 1|breast and ovarian cancer susceptibility protein 1
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Interactome
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Pathway
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Publication Reference
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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.
Yoshio Miki, Jeff Swensen, Donna Shattuck-Eidens, P. Andrew Futreal, Keith Harshman, Sean Tavtigian, Qingyun Liu, Charles Cochran, L. Michelle Bennett, Wei Ding, Russell Bell, Judith Rosenthal, Charles Hussey, Thanh Tran, Melody McClure, Cheryl Frye, Tom Hattier, Robert Phelps, Astrid Haugen-Strano, Harold Katcher, Kazuko Yakumo, Zahra Gholami, Daniel Shaffer, Steven Stone, Steven Bayer, Christian Wray, Robert Bogden, Priya Dayananth, John Ward, Patricia Tonin, Steven Narod, Pam K. Bristow, Fran
Science 1994 Oct; 266(5182):66.
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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.
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