GCG monoclonal antibody, clone K79bB10
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against native GCG.
Immunogen
Native from porcine glucagon.
Host
Mouse
Theoretical MW (kDa)
253.25
Reactivity
Human, Rat
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG1
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 1.2% sodium acetate (2 mg BSA, 0.01 mg sodium azide)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 1 mL of 1.2% sodium acetate or neutral PBS and concentration will be 100 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
-
Gene Info — GCG
Entrez GeneID
2641Gene Name
GCG
Gene Alias
GLP1, GLP2, GRPP
Gene Description
glucagon
Omim ID
138030Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq
Other Designations
glicentin-related polypeptide|glucagon-like peptide 1|glucagon-like peptide 2
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine.
Ida M Modvig, Daniel B Andersen, Kaare V Grunddal, Rune E Kuhre, Christoffer Martinussen, Charlotte B Christiansen, Cathrine Ørskov, Pierre Larraufie, Richard G Kay, Frank Reimann, Fiona M Gribble, Bolette Hartmann, Kirstine N Bojsen-Møller, Sten Madsbad, Nicolai J Wewer Albrechtsen, Jens J Holst.
International Journal of Obesity (2005) 2020 Sep; 44(9):1859.
Application：IHC, Rat, Pancreatic islets.
-
Structure of the human glucagon gene.
White JW, Saunders GF.
Nucleic Acids Research 1986 Jun; 14(12):4719.
-
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com