F11R monoclonal antibody, clone RM275
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More Files
- More Functions
Western Blot (Cell lysate)
Western Blot analysis of HEK293 cell lysate with F11R monoclonal antibody, clone RM275 (Cat # MAB14922).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with F11R monoclonal antibody, clone RM275 (Cat # MAB14922).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against of human F11R.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to N-terminus of human F11R.
Sequence
N/A
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:2000-1:10000)
Western Blotting (1:250-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blot analysis of HEK293 cell lysate with F11R monoclonal antibody, clone RM275 (Cat # MAB14922).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human kidney with F11R monoclonal antibody, clone RM275 (Cat # MAB14922). -
Gene Info — F11R
Entrez GeneID
50848Protein Accession#
Q9Y624Gene Name
F11R
Gene Alias
CD321, JAM, JAM-1, JAM-A, JAM1, JAMA, JCAM, KAT, PAM-1
Gene Description
F11 receptor
Omim ID
605721Gene Ontology
HyperlinkGene Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq
Other Designations
OTTHUMP00000027880|OTTHUMP00000027881|junctional adhesion molecule 1|junctional adhesion molecule A|platelet F11 receptor|platelet adhesion molecule
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Interactome
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Pathway
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Disease
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Publication Reference
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Human Epidermal Growth Factor Receptor-3 Expression Is Regulated at Transcriptional Level in Breast Cancer Settings by Junctional Adhesion Molecule-A via a Pathway Involving Beta-Catenin and FOXA1.
Rodrigo G B Cruz, Stephen F Madden, Cathy E Richards, Sri HariKrishna Vellanki, Hanne Jahns, Lance Hudson, Joanna Fay, Naoimh O'Farrell, Katherine Sheehan, Karin Jirström, Kieran Brennan, Ann M Hopkins.
Cancers 2021 Feb; 13(4):871.
Application：IHC-P, Chicken, Human, Chick embryo xenografts, Human invasive breast carcinomas, Human tissue microarray, MCF-7 cells.
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Human Epidermal Growth Factor Receptor-3 Expression Is Regulated at Transcriptional Level in Breast Cancer Settings by Junctional Adhesion Molecule-A via a Pathway Involving Beta-Catenin and FOXA1.
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