DSG2 monoclonal antibody, clone 6D8
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Specification
Product Description
Mouse monoclonal antibody raised against full length recombinant human DSG2.
Immunogen
Recombinant protein corresponding to full length human DSG2.
Host
Mouse
Theoretical MW (kDa)
165
Reactivity
Human
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (0.5-1 ug/106 cells)
Immunofluorescence (1-2 ug/mL)
Western Blotting (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunofluorescence
Flow Cytometry
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Gene Info — DSG2
Entrez GeneID
1829Protein Accession#
Q14126Gene Name
DSG2
Gene Alias
ARVC10, ARVD10, CDHF5, HDGC, MGC117034, MGC117036, MGC117037
Gene Description
desmoglein 2
Gene Ontology
HyperlinkGene Summary
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. This gene product is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10. [provided by RefSeq
Other Designations
HDGC
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Interactome
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Pathway
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Disease
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Publication Reference
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The amino- and carboxyl-terminal tails of (beta)-catenin reduce its affinity for desmoglein 2.
Wahl JK3rd, Nieset JE, Sacco-Bubulya PA, Sadler TM, Johnson KR, Wheelock MJ.
Journal of Cell Science 2000 May; 113(Pt 10):1737.
Application:WB-Ce, WB-Tr, Human, A-431, HT1080 cells.
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The human gene (DSG2) coding for HDGC, a second member of the desmoglein subfamily of the desmosomal cadherins, is, like DSG1 coding for desmoglein DGI, assigned to chromosome 18.
Arnemann J, Spurr NK, Magee AI, Buxton RS.
Genomics 1992 Jun; 13(2):484.
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The amino- and carboxyl-terminal tails of (beta)-catenin reduce its affinity for desmoglein 2.
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