FCER1A monoclonal antibody, clone AER-37 (CRA1)
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human small intestine with FCER1A monoclonal antibody, clone AER-37 (CRA1) (Cat # MAB12619) at 20 ug/mL working concentration.
Flow Cytometry
Flow cytometric analysis of human lysed whole blood with FCER1A monoclonal antibody, clone AER-37 (CRA1) (Cat # MAB12619) (blue histogram) and an isotype control mouse IgG2b (green histogram) followed by biotin-conjugated anti-mouse IgG secondary antibody and PE-conjugated streptavidin.
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Specification
Product Description
Mouse monoclonal antibody raised against human FCER1A.
Immunogen
Human FCER1A
Host
Mouse
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG2b, kappa
Recommend Usage
Flow Cytometry
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.2 (0.09% sodium azide).
Storage Instruction
Store at 4°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human small intestine with FCER1A monoclonal antibody, clone AER-37 (CRA1) (Cat # MAB12619) at 20 ug/mL working concentration.Flow Cytometry
Flow cytometric analysis of human lysed whole blood with FCER1A monoclonal antibody, clone AER-37 (CRA1) (Cat # MAB12619) (blue histogram) and an isotype control mouse IgG2b (green histogram) followed by biotin-conjugated anti-mouse IgG secondary antibody and PE-conjugated streptavidin. -
Gene Info — FCER1A
Entrez GeneID
2205Gene Name
FCER1A
Gene Alias
FCE1A, FcERI
Gene Description
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
Omim ID
147140Gene Ontology
HyperlinkGene Summary
The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.[supplied by OMIM
Other Designations
Fc IgE receptor, alpha polypeptide|Fc epsilon RI alpha-chain|Fc-epsilon RI-alpha|high affinity immunoglobulin epsilon receptor alpha-subunit|immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
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Interactome
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Pathway
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Disease
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