BPTF monoclonal antibody, clone 2F10
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant BPTF.
Immunogen
Recombinant protein corresponding to human BPTF.
Host
Mouse
Theoretical MW (kDa)
338
Reactivity
Human
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:10000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
In ascites (0.03% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis using BPTF monoclonal antibody, clone 2F10 (Cat # MAB10512) against HEK293 (1) and BPTF (aa : 503-670)-hIgGFc transfected HEK293 (2) cell lysate.Enzyme-linked Immunoabsorbent Assay
ELISA detection with BPTF monoclonal antibody, clone 2F10 (Cat # MAB10512). -
Gene Info — BPTF
Entrez GeneID
2186Gene Name
BPTF
Gene Alias
FAC1, FALZ, NURF301
Gene Description
bromodomain PHD finger transcription factor
Omim ID
601819Gene Ontology
HyperlinkGene Summary
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq
Other Designations
bromodomain and PHD domain transcription factor|fetal Alz-50 reactive clone 1|fetal Alzheimer antigen|nucleosome remodeling factor, large subunit
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