TAF4/TAF4B (Human) Cell-Based ELISA Kit
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Specification
Product Description
TAF4/TAF4B (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of TAF4/TAF4B expression in cultured cells.
Suitable Sample
Attached Cell, Loosely Attached Cell, Suspension Cell.
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Reactivity
Human, Mouse
Regulatory Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Qualitative
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Gene Info — TAF4
Entrez GeneID
6874Protein Accession#
O00268; Q92750Gene Name
TAF4
Gene Alias
FLJ41943, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Gene Description
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
Omim ID
601796Gene Ontology
HyperlinkGene Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. [provided by RefSeq
Other Designations
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD|TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD|TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD|TBP-associate
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Gene Info — TAF4B
Entrez GeneID
6875Protein Accession#
O00268; Q92750Gene Name
TAF4B
Gene Alias
TAF2C2, TAFII105
Gene Description
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
Omim ID
601689Gene Ontology
HyperlinkGene Summary
TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM
Other Designations
TATA box binding protein (TBP)-associated factor 4B|TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD|transcription initiation factor TFIID 105 kD subunit
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