INPP5D (Human) Cell-Based ELISA Kit
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Specification
Product Description
INPP5D (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of INPP5D expression in cultured cells.
Suitable Sample
Attached Cell, Loosely Attached Cell, Suspension Cell
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Calibration Range
> 5000 cells
Reactivity
Human, Mouse, Rat
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Qualitative
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Gene Info — INPP5D
Entrez GeneID
3635Gene Name
INPP5D
Gene Alias
MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN
Gene Description
inositol polyphosphate-5-phosphatase, 145kDa
Omim ID
601582Gene Ontology
HyperlinkGene Summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
SH2 containing inositol phosphatase|SH2 containing inositol phosphatase, isoform b|p150Ship|signaling inositol polyphosphate 5 phosphatase SIP-145
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Interactome
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Disease
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Publication Reference
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Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats.
Ali MA, Eid RMHM, Hanafi MY.
Life Sciences 2018 Feb; 194:196.
Application：ELISA, Rat, Serum.
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Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats.
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