APOE (Human) ELISA Kit
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Specification
Product Description
APOE (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human APOE.
Suitable Sample
Cell Culture Supernatants, CSF, Plasma, Serum.
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
0.016 to 1 ug/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — APOE
Entrez GeneID
348Gene Name
APOE
Gene Alias
AD2, LPG, MGC1571, apoprotein
Gene Description
apolipoprotein E
Gene Ontology
HyperlinkGene Summary
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq
Other Designations
apolipoprotein E3
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Interactome
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Disease
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Publication Reference
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Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy.
Chandra Sekhar Boddupalli, Shiny Nair, Glenn Belinsky, Joseph Gans, Erin Teeple, Tri-Hung Nguyen, Sameet Mehta, Lilu Guo, Martin L Kramer, Jiapeng Ruan, Honggge Wang, Matthew Davison, Dinesh Kumar, D J Vidyadhara, Bailin Zhang, Katherine Klinger, Pramod K Mistry.
Elife 2022 Aug; 11:e79830.
Application:Quant, Human, Sera.
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Comparison of Commercial ELISA Kits, a Prototype Multiplex Electrochemoluminescent Assay, and a Multiplex Bead-Based Immunoassay for Detecting a Urine-Based Bladder-Cancer-Associated Diagnostic Signature.
Furuya H, Pagano I, Chee K, Kobayashi T, Wong RS, Lee R, Rosser CJ.
Diagnostics (Basel, Switzerland) 2019 Oct; 9(4):E166.
Application:Quant, Human, Human urine samples.
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A flow cytometry-based in vitro assay reveals that formation of apolipoprotein E (ApoE)-amyloid beta complexes depends on ApoE isoform- and cell type.
Kara E, Marks JD, Roe AD, Commins C, Fan Z, Calvo-Rodriguez M, Wegmann S, Hudry E, Hyman BT.
The Journal of Biological Chemistry 2018 Aug; 293(34):13247.
Application:Quant, Human, HEK 293 cells.
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A multiplex immunoassay for the non-invasive detection of bladder cancer.
Shimizu Y, Furuya H, Bryant Greenwood P, Chan O, Dai Y, Thornquist MD, Goodison S, Rosser CJ.
Journal of Translational Medicine 2016 Jan; 14:31.
Application:ELISA, Human, Urine.
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External Validation of a Multiplex Urinary Protein Panel for the Detection of Bladder Cancer in a Multicenter Cohort.
Chen LM, Chang M, Dai Y, Chai KX, Dyrskjot L, Sanchez-Cabayo M, Szarvas T, Zwarthoff EC, Lokeswhar V, Jeronimo C, Parker AS, Ross S, Borre M, Orntoft TF, Jaeger T, Beukers W, Lopez LE, Henrique R, Young PR, Urquidi V, Goodison S, Rosser CJ.
Cancer Epidemiology, Biomarkers & Prevention 2014 Sep; 23(9):1804.
Application:ELISA, Human, Urine.
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Urinary Protein Biomarker Panel for the Detection of Recurrent Bladder Cancer.
Rosser CJ, Chang M, Dai Y, Ross S, Mengual L, Alacaraz A, Goodison S.
Cancer Epidemiology, Biomarkers & Prevention 2014 Jul; 23(7):1340.
Application:ELISA, Human, Urine.
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Multiplex Protein Signature for the Detection of Bladder Cancer in Voided Urine Samples.
Rosser CJ, Ross S, Chang M, Dai Y, Mengual L, Zhang G, Kim J, Urquidi V, Alcaraz A, Goodison S.
The Journal of Urology 2013 Dec; 190(6):2257.
Application:ELISA, Human, Urine.
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Diagnostic potential of urinary α1-antitrypsin and apolipoprotein E in the detection of bladder cancer.
Urquidi V, Goodison S, Ross S, Chang M, Dai Y, Rosser CJ.
The Journal of Urology 2012 Dec; 188(6):2377.
Application:Quant, Human, Human urine.
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A multi-analyte assay for the non-invasive detection of bladder cancer.
Goodison S, Chang M, Dai Y, Urquidi V, Rosser CJ.
PLoS One 2012 Oct; 7(10):e47469.
Application:Quant, Human, Human urine samples.
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Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK.
Proceedings of the National Academy of Sciences of the United States of America 2008 Jun; 105(25):8718.
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Apolipoprotein E genotype and memory in the sixth decade of life.
Schultz MR, Lyons MJ, Franz CE, Grant MD, Boake C, Jacobson KC, Xian H, Schellenberg GD, Eisen SA, Kremen WS.
Neurology 2008 May; 70(19 Pt 2):1771.
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Neuroinflammation in neuronopathic Gaucher disease: Role of microglia and NK cells, biomarkers, and response to substrate reduction therapy.
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